The dilemma of selecting a first line CDK4/6 inhibitor for hormone receptor-positive/HER2-negative metastatic breast cancer

The dilemma of selecting a first line CDK4/6 inhibitor for hormone receptor-positive/HER2-negative metastatic breast cancer

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The combination of an endocrine agent with a CDK4/6 inhibitor is the standard of care in the first-line setting for patients with Potpourri hormone receptor-positive, HER2-negative metastatic breast cancer.Randomized trials have demonstrated similar and significant improvements in progression-free survival using the three available CDK4/6 inhibitors and led to regulatory FPV Antennas approval.However, mature overall survival data now suggest potential differences among the various agents, suggesting an evolution in selection preferences.